Vista, 2008 and older Offices. Not XPSP3 or Windows 7+
"The vulnerability is a remote code execution vulnerability that exists in the way affected components handle specially crafted TIFF images. An attacker could exploit this vulnerability by convincing a user to preview or open a specially crafted email message, open a specially crafted file, or browse specially crafted web content. An attacker who successfully exploited the vulnerability could gain the same user rights as the current user. Users whose accounts are configured to have fewer user rights on the system could be less impacted than users who operate with administrative user rights." Microsoft
